Picolinamides and Iodoalkynes Enable Palladium‐Catalyzed syn‐Aminoalkynylation of Di‐ and Trisubstituted Alkenes to Give Pyrrolidines

Palladium‐catalyzed aminoalkynylation of electronically unbiased olefins with iodoalkynes is reported. The picolinamide auxiliary enables for the first time the syn‐selective aminoalkynylation of mono‐, di‐ and trisubstituted alkenes to afford the corresponding pyrrolidines in up to 97 % yield and a...

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Detalles Bibliográficos
Autores principales: Müller, Nicolas, Schreib, Benedikt S., Leutenegger, Sebastian U., Carreira, Erick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545406/
https://www.ncbi.nlm.nih.gov/pubmed/35445778
http://dx.doi.org/10.1002/anie.202204535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545406/
https://www.ncbi.nlm.nih.gov/pubmed/35445778
http://dx.doi.org/10.1002/anie.202204535

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