Kinesin-1, -2, and -3 motors use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport

Bidirectional cargo transport in neurons requires competing activity of motors from the kinesin-1, -2, and -3 superfamilies against cytoplasmic dynein-1. Previous studies demonstrated that when kinesin-1 attached to dynein-dynactin-BicD2 (DDB) complex, the tethered motors move slowly with a slight p...

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Detalles Bibliográficos
Autores principales: Gicking, Allison M, Ma, Tzu-Chen, Feng, Qingzhou, Jiang, Rui, Badieyan, Somayesadat, Cianfrocco, Michael A, Hancock, William O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545524/
https://www.ncbi.nlm.nih.gov/pubmed/36125250
http://dx.doi.org/10.7554/eLife.82228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545524/
https://www.ncbi.nlm.nih.gov/pubmed/36125250
http://dx.doi.org/10.7554/eLife.82228

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