A novel rhesus macaque model of Huntington’s disease recapitulates key neuropathological changes along with motor and cognitive decline

We created a new nonhuman primate model of the genetic neurodegenerative disorder Huntington’s disease (HD) by injecting a mixture of recombinant adeno-associated viral vectors, serotypes AAV2 and AAV2.retro, each expressing a fragment of human mutant HTT (mHTT) into the caudate and putamen of adult...

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Detalles Bibliográficos
Autores principales: Weiss, Alison R, Liguore, William A, Brandon, Kristin, Wang, Xiaojie, Liu, Zheng, Domire, Jacqueline S, Button, Dana, Srinivasan, Sathya, Kroenke, Christopher D, McBride, Jodi L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545527/
https://www.ncbi.nlm.nih.gov/pubmed/36205397
http://dx.doi.org/10.7554/eLife.77568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545527/
https://www.ncbi.nlm.nih.gov/pubmed/36205397
http://dx.doi.org/10.7554/eLife.77568

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