Human pharmacokinetics of XBD173 and etifoxine distinguish their potential for pharmacodynamic effects mediated by translocator protein

XBD173 and etifoxine are translocator protein (TSPO) ligands that modulate inflammatory responses in preclinical models. Limited human pharmacokinetic data is available for either molecule, and the binding affinity of etifoxine for human TSPO is unknown. To allow for design of human challenge experi...

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Detalles Bibliográficos
Autores principales: Owen, David R., Phillips, Alexandra, O’Connor, Desmond, Grey, Gabrielle, Aimola, Lina, Nicholas, Richard, Matthews, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545781/
https://www.ncbi.nlm.nih.gov/pubmed/35524344
http://dx.doi.org/10.1111/bcp.15392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545781/
https://www.ncbi.nlm.nih.gov/pubmed/35524344
http://dx.doi.org/10.1111/bcp.15392

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