Structure‐Based Demystification of Radical Catalysis by a Coenzyme B(12) Dependent Enzyme—Crystallographic Study of Glutamate Mutase with Cofactor Homologues

Catalysis by radical enzymes dependent on coenzyme B(12) (AdoCbl) relies on the reactive primary 5′‐deoxy‐5′adenosyl radical, which originates from reversible Co−C bond homolysis of AdoCbl. This bond homolysis is accelerated roughly 10(12)‐fold upon binding the enzyme substrate. The structural basis...

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Detalles Bibliográficos
Autores principales: Gruber, Karl, Csitkovits, Vanessa, Łyskowski, Andrzej, Kratky, Christoph, Kräutler, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545868/
https://www.ncbi.nlm.nih.gov/pubmed/35793207
http://dx.doi.org/10.1002/anie.202208295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545868/
https://www.ncbi.nlm.nih.gov/pubmed/35793207
http://dx.doi.org/10.1002/anie.202208295

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