A sensitive LC‐MS/MS method for quantification of phenytoin and its major metabolite with application to in vivo investigations of intravenous and intranasal phenytoin delivery

Phenytoin is a powerful antiseizure drug with complex pharmacokinetic properties, making it an interesting model drug to use in preclinical in vivo investigations, especially with regards to formulations aiming to improve drug delivery to the brain. Moreover, it has a major metabolite, 5‐(4‐hydroxyp...

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Detalles Bibliográficos
Autores principales: Prentice, Richard N., Younus, Mohammad, Rizwan, Shakila B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Liquid Chromatography
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545894/
https://www.ncbi.nlm.nih.gov/pubmed/35588117
http://dx.doi.org/10.1002/jssc.202200025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9545894/
https://www.ncbi.nlm.nih.gov/pubmed/35588117
http://dx.doi.org/10.1002/jssc.202200025

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