BRD4 degradation blocks expression of MYC and multiple forms of stem cell resistance in Ph(+) chronic myeloid leukemia

In most patients with chronic myeloid leukemia (CML) clonal cells can be kept under control by BCR::ABL1 tyrosine kinase inhibitors (TKI). However, overt resistance or intolerance against these TKI may occur. We identified the epigenetic reader BRD4 and its downstream‐effector MYC as growth regulato...

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Detalles Bibliográficos
Autores principales: Peter, Barbara, Eisenwort, Gregor, Sadovnik, Irina, Bauer, Karin, Willmann, Michael, Rülicke, Thomas, Berger, Daniela, Stefanzl, Gabriele, Greiner, Georg, Hoermann, Gregor, Keller, Alexandra, Wolf, Dominik, Čulen, Martin, Winter, Georg E., Hoffmann, Thomas, Schiefer, Ana‐Iris, Sperr, Wolfgang R., Zuber, Johannes, Mayer, Jiří, Valent, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546315/
https://www.ncbi.nlm.nih.gov/pubmed/35794848
http://dx.doi.org/10.1002/ajh.26650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546315/
https://www.ncbi.nlm.nih.gov/pubmed/35794848
http://dx.doi.org/10.1002/ajh.26650

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