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The mismatch recognition protein MutSα promotes nascent strand degradation at stalled replication forks

Mismatch repair (MMR) is a replication-coupled DNA repair mechanism and plays multiple roles at the replication fork. The well-established MMR functions include correcting misincorporated nucleotides that have escaped the proofreading activity of DNA polymerases, recognizing nonmismatched DNA adduct...

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Detalles Bibliográficos
Autores principales: Zhang, Junqiu, Zhao, Xin, Liu, Lu, Li, Hao-Dong, Gu, Liya, Castrillon, Diego H., Li, Guo-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546528/
https://www.ncbi.nlm.nih.gov/pubmed/36161943
http://dx.doi.org/10.1073/pnas.2201738119