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Quantitative prediction and measurement of Piezo's membrane footprint

Piezo proteins are mechanosensitive ion channels that can locally curve the membrane into a dome shape [Y. R. Guo, R. MacKinnon, eLife 6, e33660 (2017)]. The curved shape of the Piezo dome is expected to deform the surrounding lipid bilayer membrane into a membrane footprint, which may serve to ampl...

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Detalles Bibliográficos
Autores principales: Haselwandter, Christoph A., Guo, Yusong R., Fu, Ziao, MacKinnon, Roderick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546538/
https://www.ncbi.nlm.nih.gov/pubmed/36166475
http://dx.doi.org/10.1073/pnas.2208027119