ASPM promotes ATR-CHK1 activation and stabilizes stalled replication forks in response to replication stress

ASPM is a protein encoded by primary microcephaly 5 (MCPH5) and is responsible for ensuring spindle position during mitosis and the symmetrical division of neural stem cells. We recently reported that ASPM promotes homologous recombination (HR) repair of DNA double strand breaks. However, its potent...

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Detalles Bibliográficos
Autores principales: Wu, Xingxuan, Xu, Shibin, Wang, Peipei, Wang, Zhao-Qi, Chen, Hongxiang, Xu, Xingzhi, Peng, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546549/
https://www.ncbi.nlm.nih.gov/pubmed/36161901
http://dx.doi.org/10.1073/pnas.2203783119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546549/
https://www.ncbi.nlm.nih.gov/pubmed/36161901
http://dx.doi.org/10.1073/pnas.2203783119

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