G protein–biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer’s disease mouse model

Biased G protein–coupled receptor (GPCR) ligands, which preferentially activate G protein or β-arrestin signaling pathways, are leading to the development of drugs with superior efficacy and reduced side effects in heart disease, pain management, and neuropsychiatric disorders. Although GPCRs are im...

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Detalles Bibliográficos
Autores principales: Huang, Yunhong, Rafael Guimarães, Thais, Todd, Nicholas, Ferguson, Carolyn, Weiss, Kathryn M., Stauffer, Fiona R., McDermott, Breanne, Hurtle, Bryan T., Saito, Takashi, Saido, Takaomi C., MacDonald, Matthew L., Homanics, Gregg E., Thathiah, Amantha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546571/
https://www.ncbi.nlm.nih.gov/pubmed/36161942
http://dx.doi.org/10.1073/pnas.2204828119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546571/
https://www.ncbi.nlm.nih.gov/pubmed/36161942
http://dx.doi.org/10.1073/pnas.2204828119

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