Cargando…

G protein–biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer’s disease mouse model

Biased G protein–coupled receptor (GPCR) ligands, which preferentially activate G protein or β-arrestin signaling pathways, are leading to the development of drugs with superior efficacy and reduced side effects in heart disease, pain management, and neuropsychiatric disorders. Although GPCRs are im...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Yunhong, Rafael Guimarães, Thais, Todd, Nicholas, Ferguson, Carolyn, Weiss, Kathryn M., Stauffer, Fiona R., McDermott, Breanne, Hurtle, Bryan T., Saito, Takashi, Saido, Takaomi C., MacDonald, Matthew L., Homanics, Gregg E., Thathiah, Amantha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546571/ https://www.ncbi.nlm.nih.gov/pubmed/36161942 http://dx.doi.org/10.1073/pnas.2204828119

Ejemplares similares

GPCR kinases generate an APH1A phosphorylation barcode to regulate amyloid-β generation
por: Todd, Nicholas K., et al.
Publicado: (2022)

Regulation of Amyloid Precursor Protein Processing by Serotonin Signaling
por: Pimenova, Anna A., et al.
Publicado: (2014)

β-Arrestin2 arrests the clearance of tau in FTLD
por: Thathiah, Amantha
Publicado: (2020)

Metabolism of amyloid β peptide and pathogenesis of Alzheimer’s disease
por: SAIDO, Takaomi C.
Publicado: (2013)

MUC1: A multifunctional cell surface component of reproductive tissue epithelia
por: Brayman, Melissa, et al.
Publicado: (2004)

DNA Damage Increases Secreted Aβ(40) and Aβ(42) in Neuronal Progenitor Cells: Relevance to Alzheimer’s Disease
por: Welty, Starr, et al.
Publicado: (2022)

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments
por: Guix, Francesc X., et al.
Publicado: (2017)

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer’s disease
por: Thathiah, Amantha, et al.
Publicado: (2013)

Production and characterization of murine models of classic and intermediate maple syrup urine disease
por: Homanics, Gregg E, et al.
Publicado: (2006)

Repeated vapor ethanol exposure induces transient histone modifications in the brain that are modified by genotype and brain region
por: Finegersh, Andrey, et al.
Publicado: (2015)

Murine model of triosephosphate isomerase deficiency with anemia and severe neuromuscular dysfunction
por: Myers, Tracey D., et al.
Publicado: (2022)

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer’s disease
por: Sakakibara, Yasufumi, et al.
Publicado: (2019)

Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock-in mice
por: Tachida, Yuriko, et al.
Publicado: (2022)

APP mouse models for Alzheimer's disease preclinical studies
por: Sasaguri, Hiroki, et al.
Publicado: (2017)

Effects of Paternal Preconception Vapor Alcohol Exposure Paradigms on Behavioral Responses in Offspring
por: Rathod, Richa S., et al.
Publicado: (2020)

Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification
por: Kokubo, Hideko, et al.
Publicado: (2009)

Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden
por: McKee, Celia A., et al.
Publicado: (2022)

An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain
por: Ni, Junjun, et al.
Publicado: (2019)

GPR171 Agonist Reduces Chronic Neuropathic and Inflammatory Pain in Male, But Not Female Mice
por: Ram, Akila, et al.
Publicado: (2021)

GPR171 activation regulates morphine tolerance but not withdrawal in a test-dependent manner in mice
por: Afrose, Leela, et al.
Publicado: (2022)

Increased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old App(NL/NL) Knock-In Mice
por: Salas, Isabel H., et al.
Publicado: (2018)

New insight into the role of the β3 subunit of the GABA(A)-R in development, behavior, body weight regulation, and anesthesia revealed by conditional gene knockout
por: Ferguson, Carolyn, et al.
Publicado: (2007)

Paternal Alcohol Exposure Reduces Alcohol Drinking and Increases Behavioral Sensitivity to Alcohol Selectively in Male Offspring
por: Finegersh, Andrey, et al.
Publicado: (2014)

Dual roles for autophagy: Degradation and secretion of Alzheimer's disease Aβ peptide
por: Nilsson, Per, et al.
Publicado: (2014)

Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease
por: Hashimoto, Shoko, et al.
Publicado: (2018)

Neuroinflammation in mouse models of Alzheimer's disease
por: Saito, Takashi, et al.
Publicado: (2018)

New Genetic Technologies in Alcohol Research
por: Homanics, Gregg E., et al.
Publicado: (1997)

T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice
por: Wang, Shuo, et al.
Publicado: (2018)

Correction: T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice
por: Wang, Shuo, et al.
Publicado: (2019)

Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis
por: Sakakibara, Yasufumi, et al.
Publicado: (2021)

Microglia-Based Sex-Biased Neuropathology in Early-Stage Alzheimer’s Disease Model Mice and the Potential Pharmacologic Efficacy of Dioscin
por: Liu, Xiao, et al.
Publicado: (2021)

Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations
por: Andrews, Nick A., et al.
Publicado: (2015)

Synthesis and Preclinical Validation of Novel Indole Derivatives as a GPR17 Agonist for Glioblastoma Treatment
por: Nguyen, Phung, et al.
Publicado: (2021)

Selective phosphorylation of threonine residues defines GPR84–arrestin interactions of biased ligands
por: Marsango, Sara, et al.
Publicado: (2022)

Progressive Changes in Sleep and Its Relations to Amyloid-β Distribution and Learning in Single App Knock-In Mice
por: Maezono, Sakura Eri B., et al.
Publicado: (2020)

Soluble Fibre Meal Challenge Reduces Airway Inflammation and Expression of GPR43 and GPR41 in Asthma
por: Halnes, Isabel, et al.
Publicado: (2017)

Tmc Reliance Is Biased by the Hair Cell Subtype and Position Within the Ear
por: Zhu, Shaoyuan, et al.
Publicado: (2021)

Cell Surface Expression of the Major Amyloid-β Peptide (Aβ)-degrading Enzyme, Neprilysin, Depends on Phosphorylation by Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK) and Dephosphorylation by Protein Phosphatase 1a
por: Kakiya, Naomasa, et al.
Publicado: (2012)

Targeted Deletion of the Metastasis-Associated Phosphatase Ptp4a3 (PRL-3) Suppresses Murine Colon Cancer
por: Zimmerman, Mark W., et al.
Publicado: (2013)

Paternal Preconception Every-Other-Day Ethanol Drinking Alters Behavior and Ethanol Consumption in Offspring
por: Beeler, Erik, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_cai63hjkgptv5phi30ukv7b55t