Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta

Mammalian sex chromosomes encode homologous X/Y gene pairs that were retained on the Y chromosome in males and escape X chromosome inactivation (XCI) in females. Inferred to reflect X/Y pair dosage sensitivity, monosomy X is a leading cause of miscarriage in humans with near full penetrance. This ph...

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Detalles Bibliográficos
Autores principales: Ahern, Darcy T., Bansal, Prakhar, Armillei, Maria K., Faustino, Isaac V., Kondaveeti, Yuvabharath, Glatt-Deeley, Heather R., Banda, Erin C., Pinter, Stefan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546589/
https://www.ncbi.nlm.nih.gov/pubmed/36161909
http://dx.doi.org/10.1073/pnas.2211073119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546589/
https://www.ncbi.nlm.nih.gov/pubmed/36161909
http://dx.doi.org/10.1073/pnas.2211073119

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