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Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placenta

Mammalian sex chromosomes encode homologous X/Y gene pairs that were retained on the Y chromosome in males and escape X chromosome inactivation (XCI) in females. Inferred to reflect X/Y pair dosage sensitivity, monosomy X is a leading cause of miscarriage in humans with near full penetrance. This ph...

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Detalles Bibliográficos
Autores principales:	Ahern, Darcy T., Bansal, Prakhar, Armillei, Maria K., Faustino, Isaac V., Kondaveeti, Yuvabharath, Glatt-Deeley, Heather R., Banda, Erin C., Pinter, Stefan F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546589/ https://www.ncbi.nlm.nih.gov/pubmed/36161909 http://dx.doi.org/10.1073/pnas.2211073119

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