Logic-gated antibody pairs that selectively act on cells co-expressing two antigens

The use of therapeutic monoclonal antibodies is constrained because single antigen targets often do not provide sufficient selectivity to distinguish diseased from healthy tissues. We present HexElect(®), an approach to enhance the functional selectivity of therapeutic antibodies by making their act...

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Detalles Bibliográficos
Autores principales: Oostindie, Simone C., Rinaldi, Derek A., Zom, Gijs G., Wester, Michael J., Paulet, Desiree, Al-Tamimi, Kusai, van der Meijden, Els, Scheick, Jennifer R., Wilpshaar, Tessa, de Jong, Bart, Hoff-van den Broek, Marloes, Grattan, Rachel M., Oosterhoff, Janita J., Vignau, Julie, Verploegen, Sandra, Boross, Peter, Beurskens, Frank J., Lidke, Diane S., Schuurman, Janine, de Jong, Rob N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546771/
https://www.ncbi.nlm.nih.gov/pubmed/35879362
http://dx.doi.org/10.1038/s41587-022-01384-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546771/
https://www.ncbi.nlm.nih.gov/pubmed/35879362
http://dx.doi.org/10.1038/s41587-022-01384-1

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