Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue

Genome-wide mutation analyses have revealed that specific anti-cancer drugs are highly mutagenic to cancer cells, but the mutational impact of anti-cancer therapies on normal cells is not known. Here, we examine genome-wide somatic mutation patterns in 42 healthy adult stem cells (ASCs) of the colon...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuijk, Ewart, Kranenburg, Onno, Cuppen, Edwin, Van Hoeck, Arne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546852/
https://www.ncbi.nlm.nih.gov/pubmed/36207433
http://dx.doi.org/10.1038/s41467-022-33663-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546852/
https://www.ncbi.nlm.nih.gov/pubmed/36207433
http://dx.doi.org/10.1038/s41467-022-33663-5

Ejemplares similares