CDK4/6 initiates Rb inactivation and CDK2 activity coordinates cell-cycle commitment and G1/S transition

External signaling controls cell-cycle entry until cells irreversibly commit to the cell cycle to ensure faithful DNA replication. This process is tightly regulated by cyclin-dependent kinases (CDKs) and the retinoblastoma protein (Rb). Here, using live-cell sensors for CDK4/6 and CDK2 activities, w...

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Detalles Bibliográficos
Autores principales: Kim, Sungsoo, Leong, Alessandra, Kim, Minah, Yang, Hee Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546874/
https://www.ncbi.nlm.nih.gov/pubmed/36207346
http://dx.doi.org/10.1038/s41598-022-20769-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546874/
https://www.ncbi.nlm.nih.gov/pubmed/36207346
http://dx.doi.org/10.1038/s41598-022-20769-5

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