Prevalence and mechanisms of somatic deletions in single human neurons during normal aging and in DNA repair disorders

Replication errors and various genotoxins cause DNA double-strand breaks (DSBs) where error-prone repair creates genomic mutations, most frequently focal deletions, and defective repair may lead to neurodegeneration. Despite its pathophysiological importance, the extent to which faulty DSB repair al...

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Detalles Bibliográficos
Autores principales: Kim, Junho, Huang, August Yue, Johnson, Shelby L., Lai, Jenny, Isacco, Laura, Jeffries, Ailsa M., Miller, Michael B., Lodato, Michael A., Walsh, Christopher A., Lee, Eunjung Alice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546902/
https://www.ncbi.nlm.nih.gov/pubmed/36207339
http://dx.doi.org/10.1038/s41467-022-33642-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546902/
https://www.ncbi.nlm.nih.gov/pubmed/36207339
http://dx.doi.org/10.1038/s41467-022-33642-w

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