SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4

TGF-β signaling is involved in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis, representing one of the four major pathways genetically altered in 100% of PDAC cases. TGF-β exerts complex and pleiotropic effects in cancers, notably via the activation of SMAD pathways, predominantly SMAD2/3/4....

Descripción completa

Detalles Bibliográficos
Autores principales: Bertrand-Chapel, Adrien, Caligaris, Cassandre, Fenouil, Tanguy, Savary, Clara, Aires, Sophie, Martel, Sylvie, Huchedé, Paul, Chassot, Christelle, Chauvet, Véronique, Cardot-Ruffino, Victoire, Morel, Anne-Pierre, Subtil, Fabien, Mohkam, Kayvan, Mabrut, Jean-Yves, Tonon, Laurie, Viari, Alain, Cassier, Philippe, Hervieu, Valérie, Castets, Marie, Mauviel, Alain, Sentis, Stéphanie, Bartholin, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546935/
https://www.ncbi.nlm.nih.gov/pubmed/36207615
http://dx.doi.org/10.1038/s42003-022-03994-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546935/
https://www.ncbi.nlm.nih.gov/pubmed/36207615
http://dx.doi.org/10.1038/s42003-022-03994-6

Ejemplares similares