High-resolution genome topology of human retina uncovers super enhancer-promoter interactions at tissue-specific and multifactorial disease loci

Chromatin organization and enhancer-promoter contacts establish unique spatiotemporal gene expression patterns in distinct cell types. Non-coding genetic variants can influence cellular phenotypes by modifying higher-order transcriptional hubs and consequently gene expression. To elucidate genomic r...

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Detalles Bibliográficos
Autores principales: Marchal, Claire, Singh, Nivedita, Batz, Zachary, Advani, Jayshree, Jaeger, Catherine, Corso-Díaz, Ximena, Swaroop, Anand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547065/
https://www.ncbi.nlm.nih.gov/pubmed/36207300
http://dx.doi.org/10.1038/s41467-022-33427-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547065/
https://www.ncbi.nlm.nih.gov/pubmed/36207300
http://dx.doi.org/10.1038/s41467-022-33427-1

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