High-resolution structures of a siderophore-producing cyclization domain from Yersinia pestis offer a refined proposal of substrate binding

Nonribosomal peptide synthetase heterocyclization (Cy) domains generate biologically important oxazoline/thiazoline groups found in natural products, including pharmaceuticals and virulence factors such as some siderophores. Cy domains catalyze consecutive condensation and cyclodehydration reactions...

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Detalles Bibliográficos
Autores principales: Gnann, Andrew D., Xia, Yuan, Soule, Jess, Barthélemy, Clara, Mawani, Jayata S., Musoke, Sarah Nzikoba, Castellano, Brian M., Brignole, Edward J., Frueh, Dominique P., Dowling, Daniel P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547227/
https://www.ncbi.nlm.nih.gov/pubmed/36063993
http://dx.doi.org/10.1016/j.jbc.2022.102454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547227/
https://www.ncbi.nlm.nih.gov/pubmed/36063993
http://dx.doi.org/10.1016/j.jbc.2022.102454

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