FGF15 promotes hepatic NPC1L1 degradation in lithogenic diet-fed mice

BACKGROUND: Cholesterol gallstone disease (CGD) is accompanied by biliary cholesterol supersaturation. Hepatic Niemann-Pick C1-like 1 (NPC1L1), which is present in humans but not in wild-type (WT) mice, promotes hepatocyte cholesterol uptake and decreases biliary cholesterol supersaturation. In cont...

Descripción completa

Detalles Bibliográficos
Autores principales: Mo, Pingfan, Chen, Hongtan, Jiang, Xin, Hu, Fengling, Zhang, Fenming, Shan, Guodong, Chen, Wenguo, Li, Sha, Li, Yiqiao, Xu, Guoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547418/
https://www.ncbi.nlm.nih.gov/pubmed/36209166
http://dx.doi.org/10.1186/s12944-022-01709-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547418/
https://www.ncbi.nlm.nih.gov/pubmed/36209166
http://dx.doi.org/10.1186/s12944-022-01709-8

Ejemplares similares