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FGF15 promotes hepatic NPC1L1 degradation in lithogenic diet-fed mice
BACKGROUND: Cholesterol gallstone disease (CGD) is accompanied by biliary cholesterol supersaturation. Hepatic Niemann-Pick C1-like 1 (NPC1L1), which is present in humans but not in wild-type (WT) mice, promotes hepatocyte cholesterol uptake and decreases biliary cholesterol supersaturation. In cont...
Autores principales: | Mo, Pingfan, Chen, Hongtan, Jiang, Xin, Hu, Fengling, Zhang, Fenming, Shan, Guodong, Chen, Wenguo, Li, Sha, Li, Yiqiao, Xu, Guoqiang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547418/ https://www.ncbi.nlm.nih.gov/pubmed/36209166 http://dx.doi.org/10.1186/s12944-022-01709-8 |
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