Mesoporous silica nanoparticle-encapsulated Bifidobacterium attenuates brain Aβ burden and improves olfactory dysfunction of APP/PS1 mice by nasal delivery

BACKGROUND: Dysbiosis or imbalance of gut microbiota in Alzheimer's disease (AD) affects the production of short-chain fatty acids (SCFAs), whereas exogenous SCFAs supplementation exacerbates brain Aβ burden in APP/PS1 mice. Bifidobacterium is the main producer of SCFAs in the gut flora, but or...

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Detalles Bibliográficos
Autores principales: Liu, Ni, Yang, Changwen, Liang, Xiaohan, Cao, Kai, Xie, Jun, Luo, Qingming, Luo, Haiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547428/
https://www.ncbi.nlm.nih.gov/pubmed/36207740
http://dx.doi.org/10.1186/s12951-022-01642-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547428/
https://www.ncbi.nlm.nih.gov/pubmed/36207740
http://dx.doi.org/10.1186/s12951-022-01642-z

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