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Mesoporous silica nanoparticle-encapsulated Bifidobacterium attenuates brain Aβ burden and improves olfactory dysfunction of APP/PS1 mice by nasal delivery

BACKGROUND: Dysbiosis or imbalance of gut microbiota in Alzheimer's disease (AD) affects the production of short-chain fatty acids (SCFAs), whereas exogenous SCFAs supplementation exacerbates brain Aβ burden in APP/PS1 mice. Bifidobacterium is the main producer of SCFAs in the gut flora, but or...

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Detalles Bibliográficos
Autores principales:	Liu, Ni, Yang, Changwen, Liang, Xiaohan, Cao, Kai, Xie, Jun, Luo, Qingming, Luo, Haiming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547428/ https://www.ncbi.nlm.nih.gov/pubmed/36207740 http://dx.doi.org/10.1186/s12951-022-01642-z

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