Tofacitinib Inhibits STAT Phosphorylation and Matrix Metalloproteinase-3, -9 and -13 Production by C28/I2 Human Juvenile Chondrocytes

PURPOSE: This in vitro study was designed to determine the effect of the pan-Janus kinase inhibitor, Tofacitinib, on basal and interleukin-6 (IL-6)-induced signal transducers and activators of transcription (STAT) phosphorylation and matrix metalloproteinase (MMP) gene expression and MMP production...

Descripción completa

Detalles Bibliográficos
Autores principales: Thorpe, Jessica R, Wilson, Rachel A, Mesiano, Sam, Malemud, Charles J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547596/
https://www.ncbi.nlm.nih.gov/pubmed/36217356
http://dx.doi.org/10.2147/OARRR.S363736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547596/
https://www.ncbi.nlm.nih.gov/pubmed/36217356
http://dx.doi.org/10.2147/OARRR.S363736

Ejemplares similares