Cargando…

Tofacitinib Inhibits STAT Phosphorylation and Matrix Metalloproteinase-3, -9 and -13 Production by C28/I2 Human Juvenile Chondrocytes

PURPOSE: This in vitro study was designed to determine the effect of the pan-Janus kinase inhibitor, Tofacitinib, on basal and interleukin-6 (IL-6)-induced signal transducers and activators of transcription (STAT) phosphorylation and matrix metalloproteinase (MMP) gene expression and MMP production...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thorpe, Jessica R, Wilson, Rachel A, Mesiano, Sam, Malemud, Charles J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547596/ https://www.ncbi.nlm.nih.gov/pubmed/36217356 http://dx.doi.org/10.2147/OARRR.S363736

Ejemplares similares

Matrix Metalloproteinase-9 Production by Immortalized Human Chondrocyte Lines
por: Malemud, Charles J., et al.
Publicado: (2016)

Phosphorylation of STAT proteins by recombinant human IL-6 in immortalized human chondrocyte cell lines, T/C28a2 and C28/I2
por: Meszaros, Evan C, et al.
Publicado: (2017)

The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes
por: Elliott, Sarah, et al.
Publicado: (2003)

Expression and function of matrix metalloproteinase (MMP)-28
por: Rodgers, Ursula R., et al.
Publicado: (2009)

Suppression of inflammatory mediators and matrix metalloproteinase (MMP)-13 by Morus alba stem extract and oxyresveratrol in RAW 264.7 cells and C28/I2 human chondrocytes
por: Wongwat, Thidarat, et al.
Publicado: (2019)

Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13
por: Long, David, et al.
Publicado: (2008)

Basic fibroblast growth factor induces matrix metalloproteinase-13 via ERK MAP kinase-altered phosphorylation and sumoylation of Elk-1 in human adult articular chondrocytes
por: Im, Hee-Jeong, et al.
Publicado: (2009)

Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back
por: Chiba, Hiromu, et al.
Publicado: (2021)

Quercetin prevent proteoglycan destruction by inhibits matrix metalloproteinase-9, matrix metalloproteinase-13, a disintegrin and metalloproteinase with thrombospondin motifs-5 expressions on osteoarthritis model rats
por: Permatasari, Dian Agustina, et al.
Publicado: (2019)

Pravastatin Reduces Matrix Metalloproteinases Expression and Promotes Cholesterol Efflux in Osteoarthritis Chondrocytes
por: Wu, Yunpeng, et al.
Publicado: (2022)

Rosmarinic acid induces rabbit articular chondrocyte differentiation by decreases matrix metalloproteinase-13 and inflammation by upregulating cyclooxygenase-2 expression
por: Eo, Seong-Hui, et al.
Publicado: (2017)

Dynamic expression of matrix metalloproteinases 2, 9 and 13 in ovariectomy-induced osteoporosis rats
por: Zheng, Xuefeng, et al.
Publicado: (2018)

Matrix metalloproteinase 28, a novel matrix metalloproteinase, is constitutively expressed in human intervertebral disc tissue and is present in matrix of more degenerated discs
por: Gruber, Helen E, et al.
Publicado: (2009)

Effect of oleanolic acid on the activity, secretion and gene expression of matrix metalloproteinase-3 in articular chondrocytes in vitro and the production of matrix metalloproteinase-3 in vivo
por: Kang, Dong-Geun, et al.
Publicado: (2017)

Matrix metalloproteinase‐13 unlucky for the forming thrombus
por: Montague, Samantha J., et al.
Publicado: (2018)

Epilysin (matrix metalloproteinase-28) contributes to airway epithelial cell survival
por: Manicone, Anne M, et al.
Publicado: (2011)

Matrix metalloproteinase-7 and matrix metalloproteinase-9 are associated with unfavourable prognosis in superficial oesophageal cancer
por: Tanioka, Y, et al.
Publicado: (2003)

Interleukin-33, matrix metalloproteinase-9, and tissue ınhibitor of matrix metalloproteinase-1 in myocardial infarction
por: Guzel, Savas, et al.
Publicado: (2013)

Interplay between Matrix Metalloproteinase-9, Matrix Metalloproteinase-2, and Interleukins in Multiple Sclerosis Patients
por: Trentini, Alessandro, et al.
Publicado: (2016)

Matrix Metalloproteinase-1 and Matrix Metalloproteinase-9 in the Aqueous Humor of Diabetic Macular Edema Patients
por: Kwon, Jin-woo, et al.
Publicado: (2016)

Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes
por: Liacini, Abdelhamid, et al.
Publicado: (2005)

Protective role of frizzled-related protein B on matrix metalloproteinase induction in mouse chondrocytes
por: Bougault, Carole, et al.
Publicado: (2014)

Isoliquiritigenin Inhibits IL-1β-Induced Production of Matrix Metalloproteinase in Articular Chondrocytes
por: Zhang, Lei, et al.
Publicado: (2018)

Retracted: Pravastatin Reduces Matrix Metalloproteinases Expression and Promotes Cholesterol Efflux in Osteoarthritis Chondrocytes
por: and Alternative Medicine, Evidence-Based Complementary
Publicado: (2023)

Furin Functions as a Nonproteolytic Chaperone for Matrix Metalloproteinase-28: MMP-28 Propeptide Sequence Requirement
por: Pavlaki, Maria, et al.
Publicado: (2011)

High glucose concentration up-regulates the expression of matrix metalloproteinase-9 and -13 in tendon cells
por: Tsai, Wen-Chung, et al.
Publicado: (2013)

Important role of matrix metalloproteinase 9 in epileptogenesis
por: Wilczynski, Grzegorz M., et al.
Publicado: (2008)

Expression of Matrix Metalloproteinase-9 in Gastric Cancer
por: R, Prathipaa, et al.
Publicado: (2021)

Correlation between expression of matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-9 (MMP-9) and angiogenesis in colorectal adenocarcinoma.
por: Kim, T. S., et al.
Publicado: (1999)

Erratum: Interleukin-33, matrix metalloproteinase-9, and tissue inhibitor of matrix metalloproteinase-1 in myocardial infarction
por: Guzel, Savas, et al.
Publicado: (2013)

Elevated Expression of Matrix Metalloproteinase-9 not Matrix Metalloproteinase-2 Contributes to Progression of Extracranial Arteriovenous Malformation
por: Wei, Ting, et al.
Publicado: (2016)

Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery
por: Bojic, Suzana, et al.
Publicado: (2018)

Correlation Between the Expression of Matrix Metalloproteinase-9, Matrix Metalloproteinase-13, Tissue Inhibitor of Metalloproteinases-1, p16 and Differentiation of Head and Neck Squamous Cell Carcinoma: A Prospective Observational Study
por: Soni, Kapil, et al.
Publicado: (2021)

High Matrix Metalloproteinase 28 Expression is Associated with Poor Prognosis in Pancreatic Adenocarcinoma
por: Liu, Na, et al.
Publicado: (2021)

Expression of Matrix Metalloproteinase-2 and -13 and Tissue Inhibitor of Metalloproteinase-4 in Varicose Veins
por: Chang, Jee Won, et al.
Publicado: (2011)

The Significance of Matrix Metalloproteinase 9 (MMP-9) and Metalloproteinase 2 (MMP-2) in Urinary Bladder Cancer
por: Kudelski, Jacek, et al.
Publicado: (2023)

Negative Regulators of JAK/STAT Signaling in Rheumatoid Arthritis and Osteoarthritis
por: Malemud, Charles J.
Publicado: (2017)

Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation
por: Nabbe, Karin CAM, et al.
Publicado: (2005)

Expression and Significance of Matrix Metalloproteinase-2 and Matrix Metalloproteinas-9 in Endometriosis
por: Barbe, Adrian Mykhailovych, et al.
Publicado: (2020)

Downregulation of microRNA-9 increases matrix metalloproteinase-13 expression levels and facilitates osteoarthritis onset
por: Zhang, Hongxin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_788d7hgsfgt7osce258n962ur0