HIF-α activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis

Patients with glioblastoma (GBM) have poor prognosis and limited treatment options, largely due to therapy resistance upon the induction of apoptosis. Ferroptosis emerges as a potential antineoplastic strategy to bypass apoptosis resistance in traditional therapeutics. Hypoxia is a fundamental hallm...

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Detalles Bibliográficos
Autores principales: Su, Xiaodong, Xie, Yuan, Zhang, Junwen, Li, Mingxin, Zhang, Qing, Jin, Guishan, Liu, Fusheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547873/
https://www.ncbi.nlm.nih.gov/pubmed/36209275
http://dx.doi.org/10.1038/s41419-022-05304-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547873/
https://www.ncbi.nlm.nih.gov/pubmed/36209275
http://dx.doi.org/10.1038/s41419-022-05304-8

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