Autism-associated CHD8 keeps proliferation of human neural progenitors in check by lengthening the G1 phase of the cell cycle

De novo mutations (DNMs) in chromodomain helicase DNA binding protein 8 (CHD8) are associated with a specific subtype of autism characterized by enlarged heads and distinct cranial features. The vast majority of these DNMs are heterozygous loss-of-function mutations with high penetrance for autism....

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Detalles Bibliográficos
Autores principales: Coakley-Youngs, Emma, Ranatunga, Medhavi, Richardson, Simon, Getti, Giulia, Shorter, Susan, Fivaz, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548376/
https://www.ncbi.nlm.nih.gov/pubmed/36222238
http://dx.doi.org/10.1242/bio.058941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548376/
https://www.ncbi.nlm.nih.gov/pubmed/36222238
http://dx.doi.org/10.1242/bio.058941

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