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Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis
Enzymatic hydrolysis of α-L-fucose from fucosylated glycoconjugates is consequential in bacterial infections and the neurodegenerative lysosomal storage disorder fucosidosis. Understanding human α-L-fucosidase catalysis, in an effort toward drug design, has been hindered by the absence of three-dime...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548408/ https://www.ncbi.nlm.nih.gov/pubmed/35907402 http://dx.doi.org/10.1016/j.str.2022.07.001 |