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Single-cell transcriptomic profiling for inferring tumor origin and mechanisms of therapeutic resistance

Head and Neck Squamous Cell Carcinoma (HNSCC) is an aggressive epithelial cancer with poor overall response rates to checkpoint inhibitor therapy (CPI) despite CPI being the recommended treatment for recurrent or metastatic HNSCC. Mechanisms of resistance to CPI in HNSCC are poorly understood. To id...

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Detalles Bibliográficos
Autores principales: Lin, Maoxuan, Sade-Feldman, Moshe, Wirth, Lori, Lawrence, Michael S., Faden, Daniel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548500/
https://www.ncbi.nlm.nih.gov/pubmed/36210388
http://dx.doi.org/10.1038/s41698-022-00314-3