Cargando…

Single-cell transcriptomic profiling for inferring tumor origin and mechanisms of therapeutic resistance

Head and Neck Squamous Cell Carcinoma (HNSCC) is an aggressive epithelial cancer with poor overall response rates to checkpoint inhibitor therapy (CPI) despite CPI being the recommended treatment for recurrent or metastatic HNSCC. Mechanisms of resistance to CPI in HNSCC are poorly understood. To id...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Maoxuan, Sade-Feldman, Moshe, Wirth, Lori, Lawrence, Michael S., Faden, Daniel L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Case Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548500/ https://www.ncbi.nlm.nih.gov/pubmed/36210388 http://dx.doi.org/10.1038/s41698-022-00314-3

Ejemplares similares

Can we infer tumor presence of single cell transcriptomes and their tumor of origin from bulk transcriptomes by machine learning?
por: Liu, Hua-Ping, et al.
Publicado: (2022)

Inferring therapeutic vulnerability within tumors through integration of pan-cancer cell line and single-cell transcriptomic profiles
por: Zhang, Weijie, et al.
Publicado: (2023)

Evolution and origin of bread wheat
por: Levy, Avraham A, et al.
Publicado: (2022)

Pseudotime Dynamics in Melanoma Single-Cell Transcriptomes Reveals Different Mechanisms of Tumor Progression
por: Loeffler-Wirth, Henry, et al.
Publicado: (2018)

Identification of prognostic hub genes and therapeutic targets for selenium deficiency in chicks model through transcriptome profiling
por: Lingamgunta, Lakshman Kumar, et al.
Publicado: (2023)

Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors
por: Graf, Monika, et al.
Publicado: (2022)

T cell fate and clonality inference from single cell transcriptomes
por: Stubbington, Michael J.T., et al.
Publicado: (2016)

Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics
por: Street, Kelly, et al.
Publicado: (2018)

Parent-of-Origin inference for biobanks
por: Hofmeister, Robin J., et al.
Publicado: (2022)

CVAM: CNA Profile Inference of the Spatial Transcriptome Based on the VGAE and HMM
por: Ma, Jian, et al.
Publicado: (2023)

MBRS-03. SINGLE NUCLEUS TRANSCRIPTOME PROFILES FROM HUMAN DEVELOPING CEREBELLUM REVEAL POTENTIAL CELLULAR ORIGINS OF MEDULLOBLASTOMA BRAIN TUMORS
por: Okonechnikov, Konstantin, et al.
Publicado: (2020)

SCONCE2: jointly inferring single cell copy number profiles and tumor evolutionary distances
por: Hui, Sandra, et al.
Publicado: (2022)

APOBEC Mutagenesis Is Concordant between Tumor and Viral Genomes in HPV-Positive Head and Neck Squamous Cell Carcinoma
por: Faden, Daniel L., et al.
Publicado: (2021)

SingleCellSignalR: inference of intercellular networks from single-cell transcriptomics
por: Cabello-Aguilar, Simon, et al.
Publicado: (2020)

scKINETICS: inference of regulatory velocity with single-cell transcriptomics data
por: Burdziak, Cassandra, et al.
Publicado: (2023)

Origin and interpretation of cancer transcriptome profiling: the essential role of the stroma in determining prognosis and drug resistance
por: Goossens, Nicolas, et al.
Publicado: (2015)

On the Origins of Suboptimality in Human Probabilistic Inference
por: Acerbi, Luigi, et al.
Publicado: (2014)

Population-Genetic Inference from Pooled-Sequencing Data
por: Lynch, Michael, et al.
Publicado: (2014)

Cellular crosstalk of macrophages and therapeutic implications in non-small cell lung cancer revealed by integrative inference of single-cell transcriptomics
por: Wu, Lei, et al.
Publicado: (2023)

Inference on spatial heterogeneity in tumor microenvironment using spatial transcriptomics data
por: Biswas, Antara, et al.
Publicado: (2022)

Computational inference of mRNA stability from histone modification and transcriptome profiles
por: Wang, Chengyang, et al.
Publicado: (2012)

Origin and Demographic History of Philippine Pigs Inferred from Mitochondrial DNA
por: Layos, John King N., et al.
Publicado: (2022)

Cell lineage and communication network inference via optimization for single-cell transcriptomics
por: Wang, Shuxiong, et al.
Publicado: (2019)

Single-cell and spatial transcriptomics enables probabilistic inference of cell type topography
por: Andersson, Alma, et al.
Publicado: (2020)

Tempo: an unsupervised Bayesian algorithm for circadian phase inference in single-cell transcriptomics
por: Auerbach, Benjamin J., et al.
Publicado: (2022)

Inferring single-cell transcriptomic dynamics with structured latent gene expression dynamics
por: Farrell, Spencer, et al.
Publicado: (2023)

Single-cell transcriptomics reveals expression profiles of Trypanosoma brucei sexual stages
por: Howick, Virginia M., et al.
Publicado: (2022)

Single-Cell Transcriptomics for Unlocking Personalized Cancer Immunotherapy: Toward Targeting the Origin of Tumor Development Immunogenicity
por: Khodayari, Saeed, et al.
Publicado: (2023)

Inferring Unseen Causes: Developmental and Evolutionary Origins
por: Civelek, Zeynep, et al.
Publicado: (2020)

Inference of differentiation time for single cell transcriptomes using cell population reference data
por: Sun, Na, et al.
Publicado: (2017)

Inference and multiscale model of epithelial-to-mesenchymal transition via single-cell transcriptomic data
por: Sha, Yutong, et al.
Publicado: (2020)

Inferring spatial and signaling relationships between cells from single cell transcriptomic data
por: Cang, Zixuan, et al.
Publicado: (2020)

Benchmarking algorithms for gene regulatory network inference from single-cell transcriptomic data
por: Pratapa, Aditya, et al.
Publicado: (2020)

VEGA is an interpretable generative model for inferring biological network activity in single-cell transcriptomics
por: Seninge, Lucas, et al.
Publicado: (2021)

A Bayesian inference transcription factor activity model for the analysis of single-cell transcriptomes
por: Gao, Shang, et al.
Publicado: (2021)

Inferring neuron-neuron communications from single-cell transcriptomics through NeuronChat
por: Zhao, Wei, et al.
Publicado: (2023)

Inferring neuron-neuron communications from single-cell transcriptomics through NeuronChat
por: Zhao, Wei, et al.
Publicado: (2023)

Inferring gene regulatory network from single-cell transcriptomes with graph autoencoder model
por: Wang, Jiacheng, et al.
Publicado: (2023)

Evaluating DNA Methylation, Gene Expression, Somatic Mutation, and Their Combinations in Inferring Tumor Tissue-of-Origin
por: Liu, Haiyan, et al.
Publicado: (2021)

CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells
por: Shafighi, Shadi Darvish, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4q1uoatf96pfqh1jml6s58aiu5