Development of a pediatric physiologically-based pharmacokinetic model to support recommended dosing of atezolizumab in children with solid tumors

Background: Atezolizumab has been studied in multiple indications for both pediatric and adult patient populations. Generally, clinical studies enrolling pediatric patients may not collect sufficient pharmacokinetic data to characterize the drug exposure and disposition because of operational, ethic...

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Detalles Bibliográficos
Autores principales: Huang, Weize, Stader, Felix, Chan, Phyllis, Shemesh, Colby S., Chen, Yuan, Gill, Katherine L., Jones, Hannah M., Li, Linzhong, Rossato, Gianluca, Wu, Benjamin, Jin, Jin Y., Chanu, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548535/
https://www.ncbi.nlm.nih.gov/pubmed/36225583
http://dx.doi.org/10.3389/fphar.2022.974423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548535/
https://www.ncbi.nlm.nih.gov/pubmed/36225583
http://dx.doi.org/10.3389/fphar.2022.974423

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