Pharmacogenetic inhibition of TrkB signaling in adult mice attenuates mechanical hypersensitivity and improves locomotor function after spinal cord injury

Brain-derived neurotrophic factor (BDNF) signals through tropomyosin receptor kinase B (TrkB), to exert various types of plasticity. The exact involvement of BDNF and TrkB in neuropathic pain states after spinal cord injury (SCI) remains unresolved. This study utilized transgenic TrkBF616 mice to ex...

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Detalles Bibliográficos
Autores principales: Martin, Karmarcha K., Noble, Donald J., Parvin, Shangrila, Jang, Kyeongran, Garraway, Sandra M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548551/
https://www.ncbi.nlm.nih.gov/pubmed/36226073
http://dx.doi.org/10.3389/fncel.2022.987236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548551/
https://www.ncbi.nlm.nih.gov/pubmed/36226073
http://dx.doi.org/10.3389/fncel.2022.987236

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