Cargando…

Analysis of two cooperating antibodies unveils immune pressure imposed on HIV Env to elicit a V3-glycan supersite broadly neutralizing antibody lineage

Elicitation of broadly neutralizing antibodies (bnAbs) is a goal of vaccine design as a strategy for targeting highly divergent strains of HIV-1. Current HIV-1 vaccine design efforts seek to elicit bnAbs by first eliciting their precursors through prime-boost regimens. This requires an understanding...

Descripción completa

Detalles Bibliográficos
Autores principales:	Finkelstein, Maxwell T., Parker Miller, Emma, Erdman, Molly C., Fera, Daniela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9548623/ https://www.ncbi.nlm.nih.gov/pubmed/36225920 http://dx.doi.org/10.3389/fimmu.2022.962939

Ejemplares similares

HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite
por: Nogal, Bartek, et al.
Publicado: (2020)

Recognition and penetration of the HIV-1 Env glycan shield by potent broadly neutralizing antibodies
por: Julien, J, et al.
Publicado: (2012)

A V(H)1-69 antibody lineage from an infected Chinese donor potently neutralizes HIV-1 by targeting the V3 glycan supersite
por: Kumar, Sonu, et al.
Publicado: (2020)

Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability
por: Shi, Wei, et al.
Publicado: (2022)

Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability
por: Shi, Wei, et al.
Publicado: (2022)

Glycan Positioning Impacts HIV-1 Env Glycan-Shield Density, Function, and Recognition by Antibodies
por: Wei, Qing, et al.
Publicado: (2020)

An NTD supersite of attack
por: Lok, Shee-Mei
Publicado: (2021)

A neutralizing-protective supersite of human monoclonal antibodies for yellow fever virus
por: Li, Yan, et al.
Publicado: (2022)

The Effects of Framework Mutations at the Variable Domain Interface on Antibody Affinity Maturation in an HIV-1 Broadly Neutralizing Antibody Lineage
por: Zhou, Jeffrey O., et al.
Publicado: (2020)

Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response
por: Dubrovskaya, Viktoriya, et al.
Publicado: (2017)

Corrigendum: The Effects of Framework Mutations at the Variable Domain Interface on Antibody Affinity Maturation in an HIV-1 Broadly Neutralizing Antibody Lineage
por: Zhou, Jeffrey O., et al.
Publicado: (2020)

Protein—protein binding supersites
por: Viswanathan, Raji, et al.
Publicado: (2019)

Neutralizing antibodies elicited in rabbits by patient-derived Env trimer immunization
por: Heyndrickx, L, et al.
Publicado: (2012)

Transplanting Supersites of HIV-1 Vulnerability
por: Zhou, Tongqing, et al.
Publicado: (2014)

Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies
por: Zhu, Cheng, et al.
Publicado: (2019)

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability
por: Dubrovskaya, Viktoriya, et al.
Publicado: (2019)

Cross-reactivity of glycan-reactive HIV-1 broadly neutralizing antibodies with parasite glycans
por: Huettner, Isabella, et al.
Publicado: (2022)

Correction: Transplanting Supersites of HIV-1 Vulnerability
Publicado: (2014)

The HIV glycan shield as a target for broadly neutralizing antibodies
por: Doores, Katie J.
Publicado: (2015)

Profiles of Human Serum Antibody Responses Elicited by Three Leading HIV Vaccines Focusing on the Induction of Env-Specific Antibodies
por: Vaine, Michael, et al.
Publicado: (2010)

A1 The role of virus-antibody co-evolution in the development of a V3-glycan-directed HIV-1 broadly neutralizing antibody lineage
por: Kitchin, D, et al.
Publicado: (2019)

Glycoengineering HIV-1 Env creates ‘supercharged’ and ‘hybrid’ glycans to increase neutralizing antibody potency, breadth and saturation
por: Crooks, Ema T., et al.
Publicado: (2018)

A Structural Update of Neutralizing Epitopes on the HIV Envelope, a Moving Target
por: Parker Miller, Emma, et al.
Publicado: (2021)

Repeated Vaccination of Cows with HIV Env gp140 during Subsequent Pregnancies Elicits and Sustains an Enduring Strong Env-Binding and Neutralising Antibody Response
por: Heydarchi, Behnaz, et al.
Publicado: (2016)

Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants
por: Lin, Wei-Shuo, et al.
Publicado: (2021)

Designer antigens for elicitation of broadly neutralizing antibodies against HIV
por: Kok, Tuckweng, et al.
Publicado: (2014)

Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows
por: Sok, Devin, et al.
Publicado: (2017)

Development of an anti-HIV vaccine eliciting broadly neutralizing antibodies
por: Ahmed, Yousuf, et al.
Publicado: (2017)

SuperSite: dictionary of metabolite and drug binding sites in proteins
por: Bauer, Raphael André, et al.
Publicado: (2009)

Highly mutated antibodies capable of neutralizing N276 glycan-deficient HIV after a single immunization with an Env trimer
por: Lee, Jeong Hyun, et al.
Publicado: (2022)

Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite
por: Cerutti, Gabriele, et al.
Publicado: (2021)

Hidden Lineage Complexity of Glycan-Dependent HIV-1 Broadly Neutralizing Antibodies Uncovered by Digital Panning and Native-Like gp140 Trimer
por: He, Linling, et al.
Publicado: (2017)

HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope
por: Fera, Daniela, et al.
Publicado: (2018)

Viral neutralization by antibody-imposed physical disruption
por: Zheng, Qingbing, et al.
Publicado: (2019)

Stabilized coronavirus spike stem elicits a broadly protective antibody
por: Hsieh, Ching-Lin, et al.
Publicado: (2021)

Exploiting glycan topography for computational design of Env glycoprotein antigenicity
por: Yu, Wen-Han, et al.
Publicado: (2018)

Visualization of the HIV-1 Env glycan shield across scales
por: Berndsen, Zachary T., et al.
Publicado: (2020)

P19-06. The first hypervariable loop and HIV-1 neutralizing antibodies elicited by gp140 env immunogens
por: Ching, LK, et al.
Publicado: (2009)

Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope
por: Abernathy, Morgan E., et al.
Publicado: (2021)

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies
por: Steichen, Jon M., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_5u0u2haopnav2msnsm7vdtihal