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Sucralose consumption ameliorates high-fat diet-induced glucose intolerance and liver weight gain in mice

Sucralose is one of the most widely used artificial sweeteners used by the food industry to reduce the calorie density of their products. Although broadly regarded as innocuous, studies show contrasting results depending on whether the research subjects are lean or overweight. In this study, we stud...

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Autores principales: Pino-Seguel, Pamela, Moya, Omara, Borquez, Juan Carlos, Pino-de la Fuente, Francisco, Díaz-Castro, Francisco, Donoso-Barraza, Camila, Llanos, Miguel, Troncoso, Rodrigo, Bravo-Sagua, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549123/
https://www.ncbi.nlm.nih.gov/pubmed/36225871
http://dx.doi.org/10.3389/fnut.2022.979624
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author Pino-Seguel, Pamela
Moya, Omara
Borquez, Juan Carlos
Pino-de la Fuente, Francisco
Díaz-Castro, Francisco
Donoso-Barraza, Camila
Llanos, Miguel
Troncoso, Rodrigo
Bravo-Sagua, Roberto
author_facet Pino-Seguel, Pamela
Moya, Omara
Borquez, Juan Carlos
Pino-de la Fuente, Francisco
Díaz-Castro, Francisco
Donoso-Barraza, Camila
Llanos, Miguel
Troncoso, Rodrigo
Bravo-Sagua, Roberto
author_sort Pino-Seguel, Pamela
collection PubMed
description Sucralose is one of the most widely used artificial sweeteners used by the food industry to reduce the calorie density of their products. Although broadly regarded as innocuous, studies show contrasting results depending on whether the research subjects are lean or overweight. In this study, we studied the effect of sucralose consumption on glucose homeostasis in a model of obesity. Male C57BL/6J mice were fed ad libitum with control or a high-fat diet (HFD) and drank either water or sucralose (0.1 mg/mL) for 8 weeks. To characterize the ensuing metabolic changes, we evaluated weight gain, glucose and pyruvate tolerance, and physical performance. Also, we assessed markers of steatosis and mitochondrial mass and function in the liver. Our results show that sucralose reduced weight gain, glucose, and pyruvate intolerance, and prevented the decrease in physical performance of HFD-fed mice. In the liver, sucralose also had a positive effect, preventing the decrease in mitochondrial mass exerted by HFD. Altogether, our results indicate that in the context of an obesogenic diet, sucralose has a beneficial effect at the organismal and hepatic levels.
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spelling pubmed-95491232022-10-11 Sucralose consumption ameliorates high-fat diet-induced glucose intolerance and liver weight gain in mice Pino-Seguel, Pamela Moya, Omara Borquez, Juan Carlos Pino-de la Fuente, Francisco Díaz-Castro, Francisco Donoso-Barraza, Camila Llanos, Miguel Troncoso, Rodrigo Bravo-Sagua, Roberto Front Nutr Nutrition Sucralose is one of the most widely used artificial sweeteners used by the food industry to reduce the calorie density of their products. Although broadly regarded as innocuous, studies show contrasting results depending on whether the research subjects are lean or overweight. In this study, we studied the effect of sucralose consumption on glucose homeostasis in a model of obesity. Male C57BL/6J mice were fed ad libitum with control or a high-fat diet (HFD) and drank either water or sucralose (0.1 mg/mL) for 8 weeks. To characterize the ensuing metabolic changes, we evaluated weight gain, glucose and pyruvate tolerance, and physical performance. Also, we assessed markers of steatosis and mitochondrial mass and function in the liver. Our results show that sucralose reduced weight gain, glucose, and pyruvate intolerance, and prevented the decrease in physical performance of HFD-fed mice. In the liver, sucralose also had a positive effect, preventing the decrease in mitochondrial mass exerted by HFD. Altogether, our results indicate that in the context of an obesogenic diet, sucralose has a beneficial effect at the organismal and hepatic levels. Frontiers Media S.A. 2022-09-26 /pmc/articles/PMC9549123/ /pubmed/36225871 http://dx.doi.org/10.3389/fnut.2022.979624 Text en Copyright © 2022 Pino-Seguel, Moya, Borquez, Pino-de la Fuente, Díaz-Castro, Donoso-Barraza, Llanos, Troncoso and Bravo-Sagua. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Pino-Seguel, Pamela
Moya, Omara
Borquez, Juan Carlos
Pino-de la Fuente, Francisco
Díaz-Castro, Francisco
Donoso-Barraza, Camila
Llanos, Miguel
Troncoso, Rodrigo
Bravo-Sagua, Roberto
Sucralose consumption ameliorates high-fat diet-induced glucose intolerance and liver weight gain in mice
title Sucralose consumption ameliorates high-fat diet-induced glucose intolerance and liver weight gain in mice
title_full Sucralose consumption ameliorates high-fat diet-induced glucose intolerance and liver weight gain in mice
title_fullStr Sucralose consumption ameliorates high-fat diet-induced glucose intolerance and liver weight gain in mice
title_full_unstemmed Sucralose consumption ameliorates high-fat diet-induced glucose intolerance and liver weight gain in mice
title_short Sucralose consumption ameliorates high-fat diet-induced glucose intolerance and liver weight gain in mice
title_sort sucralose consumption ameliorates high-fat diet-induced glucose intolerance and liver weight gain in mice
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549123/
https://www.ncbi.nlm.nih.gov/pubmed/36225871
http://dx.doi.org/10.3389/fnut.2022.979624
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