Antagonistic control of active surface integrins by myotubularin and phosphatidylinositol 3-kinase C2β in a myotubular myopathy model

X-linked centronuclear myopathy (XLCNM) is a severe human disease without existing therapies caused by mutations in the phosphoinositide 3-phosphatase MTM1. Loss of MTM1 function is associated with muscle fiber defects characterized by impaired localization of β-integrins and other components of foc...

Descripción completa

Detalles Bibliográficos
Autores principales: Samsó, Paula, Koch, Philipp A., Posor, York, Lo, Wen-Ting, Belabed, Hassane, Nazare, Marc, Laporte, Jocelyn, Haucke, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549396/
https://www.ncbi.nlm.nih.gov/pubmed/36161941
http://dx.doi.org/10.1073/pnas.2202236119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549396/
https://www.ncbi.nlm.nih.gov/pubmed/36161941
http://dx.doi.org/10.1073/pnas.2202236119

Ejemplares similares