A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation

Cyclic AMP (cAMP) signaling is localized to multiple spatially distinct microdomains, but the role of cAMP microdomains in cancer cell biology is poorly understood. Here, we present a tunable genetic system that allows us to activate cAMP signaling in specific microdomains. We uncover a nuclear cAMP...

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Detalles Bibliográficos
Autores principales: Drozdz, Marek M., Doane, Ashley S., Alkallas, Rached, Desman, Garrett, Bareja, Rohan, Reilly, Michael, Bang, Jakyung, Yusupova, Maftuna, You, Jaewon, Eraslan, Zuhal, Wang, Jenny Z., Verma, Akanksha, Aguirre, Kelsey, Kane, Elsbeth, Watson, Ian R., Elemento, Olivier, Piskounova, Elena, Merghoub, Taha, Zippin, Jonathan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549417/
https://www.ncbi.nlm.nih.gov/pubmed/36170819
http://dx.doi.org/10.1016/j.celrep.2022.111412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549417/
https://www.ncbi.nlm.nih.gov/pubmed/36170819
http://dx.doi.org/10.1016/j.celrep.2022.111412

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