Cargando…

ISGylation of EMD promotes its interaction with PDHA to inhibit aerobic oxidation in lung adenocarcinoma

Abnormal nuclear structure caused by dysregulation of skeletal proteins is a common phenomenon in tumour cells. However, how skeletal proteins promote tumorigenesis remains uncovered. Here, we revealed the mechanism by which skeletal protein Emerin (EMD) promoted glucose metabolism to induce lung ad...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Congcong, Cui, Jiangtao, Cao, Leiqun, Tian, Xiaoting, Miao, Yayou, Wang, Yikun, Qiu, Shiyu, Guo, Wanxin, Ma, Lifang, Xia, Jinjing, Zhang, Xiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549505/ https://www.ncbi.nlm.nih.gov/pubmed/36071546 http://dx.doi.org/10.1111/jcmm.17536

Ejemplares similares

YAP ISGylation increases its stability and promotes its positive regulation on PPP by stimulating 6PGL transcription
por: Xue, Xiangfei, et al.
Publicado: (2022)

Transcriptional Repression of Ferritin Light Chain Increases Ferroptosis Sensitivity in Lung Adenocarcinoma
por: Wang, Yikun, et al.
Publicado: (2021)

YAP 5-methylcytosine modification increases its mRNA stability and promotes the transcription of exosome secretion-related genes in lung adenocarcinoma
por: Yu, Wenjun, et al.
Publicado: (2022)

The essential roles of m(6)A RNA modification to stimulate ENO1-dependent glycolysis and tumorigenesis in lung adenocarcinoma
por: Ma, Lifang, et al.
Publicado: (2022)

IGF2BP3 is an essential N(6)-methyladenosine biotarget for suppressing ferroptosis in lung adenocarcinoma cells
por: Xu, Xin, et al.
Publicado: (2022)

Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma
por: Zhang, Xiao, et al.
Publicado: (2022)

The m(6)A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function
por: Ma, Lifang, et al.
Publicado: (2020)

Conditional Knockout of Pdha1 in Mouse Hippocampus Impairs Cognitive Function: The Possible Involvement of Lactate
por: Chen, Wanxin, et al.
Publicado: (2021)

Differences in serum cytokine levels distinguish between clinically noninvasive lung adenocarcinoma and invasive lung adenocarcinoma: A cross‐sectional study
por: Zeng, Bingjie, et al.
Publicado: (2023)

Data supporting the co-expression of PDHA1 gene and of its paralogue PDHA2 in somatic cells of a family
por: Pinheiro, Ana, et al.
Publicado: (2016)

Tumour cells are sensitised to ferroptosis via RB1CC1‐mediated transcriptional reprogramming
por: Xue, Xiangfei, et al.
Publicado: (2022)

AP2α negatively regulates PDHA1 in cervical cancer cells to promote aggressive features and aerobic glycolysis in vitro and in vivo
por: Zhao, Lijie, et al.
Publicado: (2023)

ISG15 and ISGylation in Human Diseases
por: Mirzalieva, Oygul, et al.
Publicado: (2022)

An integrated EMD adaptive threshold denoising method for reduction of noise in ECG
por: Zhang, Miao, et al.
Publicado: (2020)

Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis
por: Cai, Zhen, et al.
Publicado: (2020)

Proteomics Mapping of the ISGylation Landscape in Innate Immunity
por: Thery, Fabien, et al.
Publicado: (2021)

The Functional Roles of ISG15/ISGylation in Cancer
por: Yuan, Yin, et al.
Publicado: (2023)

ISGylation orchestrates the degradation flux of cellular cargo toward lysosome
por: Huang, Min-Yi, et al.
Publicado: (2021)

ISG15 suppresses ovulation and female fertility by ISGylating ADAMTS1
por: Chen, Yaru, et al.
Publicado: (2023)

Thiamin-Responsive PDH Deficiency due to a PDHA1 Variant
por: Finsterer, Josef, et al.
Publicado: (2018)

Anti-PDHA1 antibody is detected in a subset of patients with schizophrenia
por: Nakagami, Yukako, et al.
Publicado: (2020)

RRM2 protects against ferroptosis and is a tumor biomarker for liver cancer
por: Yang, Yueyue, et al.
Publicado: (2020)

Oncogene-mediated regulation of p53 ISGylation and functions
por: Huang, Yi-Fu, et al.
Publicado: (2014)

Targeting the Ubiquitylation and ISGylation Machinery for the Treatment of COVID-19
por: Vere, George, et al.
Publicado: (2022)

ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A Review
por: Zhang, Mengdi, et al.
Publicado: (2021)

Correction: TRIB2 desensitizes ferroptosis via βTrCP-mediated TFRC ubiquitiantion in liver cancer cells
por: Guo, Susu, et al.
Publicado: (2021)

TRIB2 desensitizes ferroptosis via βTrCP-mediated TFRC ubiquitiantion in liver cancer cells
por: Guo, Susu, et al.
Publicado: (2021)

Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus Regulators
por: Kim, Ye Ji, et al.
Publicado: (2016)

Upregulation of Enzymes involved in ISGylation and Ubiquitination in patients with hepatocellular carcinoma
por: Tong, Hoang Van, et al.
Publicado: (2020)

Protein ISGylation: a posttranslational modification with implications for malignant neoplasms
por: Tecalco-Cruz, Angeles C., et al.
Publicado: (2023)

The Influence of Arginine on the Response of Enamel Matrix Derivative (EMD) Proteins to Thermal Stress: Towards Improving the Stability of EMD-Based Products
por: Apicella, Alessandra, et al.
Publicado: (2015)

AMPK maintains TCA cycle through sequential phosphorylation of PDHA to promote tumor metastasis
por: Cai, Zhen, et al.
Publicado: (2020)

Comprehensive analyses of PDHA1 that serves as a predictive biomarker for immunotherapy response in cancer
por: Deng, Langmei, et al.
Publicado: (2022)

HyperISGylation of Old World Monkey ISG15 in Human Cells
por: Pattyn, Els, et al.
Publicado: (2008)

ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins
por: Villarroya-Beltri, Carolina, et al.
Publicado: (2016)

Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO
por: Adapala, Naga Suresh, et al.
Publicado: (2020)

HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response
por: Mathieu, Nicholas A., et al.
Publicado: (2021)

PB2096: SELINEXOR COMBINED REGIMEN FOR MULTIPLE MYELOMA WITH EXTRAMEDULLARY DISEASE(EMD)
por: Zhong, Yuping, et al.
Publicado: (2023)

Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma
por: Zhang, Xiao, et al.
Publicado: (2021)

The energy consumption structure and African EMDEs' sustainable development
por: Le, Hoang Phong, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_85de6bckpu7a1oqrddit37ecbu