Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity

Fn14 is a cell surface receptor with key functions in tissue homeostasis and injury but is also linked to chronic diseases. Despite its physiological and medical importance, the regulation of Fn14 signaling and turnover is only partly understood. Here, we demonstrate that Fn14 is cleaved within its...

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Detalles Bibliográficos
Autores principales: Güner, Gökhan, Aßfalg, Marlene, Zhao, Kai, Dreyer, Tobias, Lahiri, Shibojyoti, Lo, Yun, Slivinschi, Bianca Ionela, Imhof, Axel, Jocher, Georg, Strohm, Laura, Behrends, Christian, Langosch, Dieter, Bronger, Holger, Nimsky, Christopher, Bartsch, Jörg W, Riddell, Stanley R, Steiner, Harald, Lichtenthaler, Stefan F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549706/
https://www.ncbi.nlm.nih.gov/pubmed/36069059
http://dx.doi.org/10.15252/emmm.202216084

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