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Safety and immunogenicity of the Na-APR-1 hookworm vaccine in infection-naïve adults

BACKGROUND: The Necator americanus hemoglobinase, aspartic protease-1 (Na-APR-1), facilitates the ability of adult hookworms to parasitize the intestine of their human hosts. A recombinant version of APR-1 protected laboratory animals against hookworm infection by inducing neutralizing antibodies th...

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Detalles Bibliográficos
Autores principales:	Diemert, David J., Zumer, Maria, Campbell, Doreen, Grahek, Shannon, Li, Guangzhao, Peng, Jin, Elena Bottazzi, Maria, Hotez, Peter, Bethony, Jeffrey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9549940/ https://www.ncbi.nlm.nih.gov/pubmed/36114129 http://dx.doi.org/10.1016/j.vaccine.2022.09.017

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