SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway

Loss of podocyte is a characteristic pathological change of diabetic nephropathy (DN) which is associated with increased proteinuria. Many studies have shown that novel inhibitors of sodium–glucose cotransporter 2 (SGLT2-is), such as dapagliflozin, exert nephroprotective effect on delaying DN progre...

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Detalles Bibliográficos
Autores principales: Guo, Ruixue, Wang, Peipei, Zheng, Xuejun, Cui, Wen, Shang, Jin, Zhao, Zhanzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550168/
https://www.ncbi.nlm.nih.gov/pubmed/36225569
http://dx.doi.org/10.3389/fphar.2022.897167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550168/
https://www.ncbi.nlm.nih.gov/pubmed/36225569
http://dx.doi.org/10.3389/fphar.2022.897167

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