Cargando…

SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway

Loss of podocyte is a characteristic pathological change of diabetic nephropathy (DN) which is associated with increased proteinuria. Many studies have shown that novel inhibitors of sodium–glucose cotransporter 2 (SGLT2-is), such as dapagliflozin, exert nephroprotective effect on delaying DN progre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Ruixue, Wang, Peipei, Zheng, Xuejun, Cui, Wen, Shang, Jin, Zhao, Zhanzheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550168/ https://www.ncbi.nlm.nih.gov/pubmed/36225569 http://dx.doi.org/10.3389/fphar.2022.897167

Ejemplares similares

Corrigendum: SGLT2 inhibitors suppress epithelial-mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway
por: Guo, Ruixue, et al.
Publicado: (2022)

Saxagliptin Attenuates Albuminuria by Inhibiting Podocyte Epithelial- to-Mesenchymal Transition via SDF-1α in Diabetic Nephropathy
por: Chang, Yun-peng, et al.
Publicado: (2017)

Network Pharmacology and Experimental Verification Strategies to Illustrate the Mechanism of Jian-Pi-Yi-Shen Formula in Suppressing Epithelial–Mesenchymal Transition
por: Zhao, Yuan, et al.
Publicado: (2022)

20(S)-Protopanaxadiol Inhibits Angiotensin II-Induced Epithelial- Mesenchymal Transition by Downregulating SIRT1
por: Wang, Yuchen, et al.
Publicado: (2019)

Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer
por: Yang, Hui-Wen, et al.
Publicado: (2023)

MiR-30a Inhibits the Epithelial—Mesenchymal Transition of Podocytes through Downregulation of NFATc3
por: Peng, Rui, et al.
Publicado: (2015)

Tangeretin attenuates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition via the PI3K/Akt pathway
por: Li, Jiang, et al.
Publicado: (2023)

α-Mangostin Suppresses the Viability and Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells by Downregulating the PI3K/Akt Pathway
por: Xu, Qinhong, et al.
Publicado: (2014)

Apelin inhibited epithelial−mesenchymal transition of podocytes in diabetic mice through downregulating immunoproteasome subunits β5i
por: Yin, Jiming, et al.
Publicado: (2018)

Evidence That Tumor Microenvironment Initiates Epithelial-To-Mesenchymal Transition and Calebin A can Suppress it in Colorectal Cancer Cells
por: Buhrmann, Constanze, et al.
Publicado: (2021)

Natural Plants Compounds as Modulators of Epithelial-to-Mesenchymal Transition
por: Avila-Carrasco, Lorena, et al.
Publicado: (2019)

Tackle Epithelial-Mesenchymal Transition With Epigenetic Drugs in Cancer
por: Dong, Bo, et al.
Publicado: (2020)

Epithelial-to-Mesenchymal Transition in Fibrosis: Concepts and Targeting Strategies
por: Lovisa, Sara
Publicado: (2021)

microRNA Crosstalk Influences Epithelial-to-Mesenchymal, Endothelial-to-Mesenchymal, and Macrophage-to-Mesenchymal Transitions in the Kidney
por: Srivastava, Swayam Prakash, et al.
Publicado: (2019)

Celastrol Ameliorates Ulcerative Colitis-Related Colorectal Cancer in Mice via Suppressing Inflammatory Responses and Epithelial-Mesenchymal Transition
por: Lin, Lianjie, et al.
Publicado: (2016)

Yi–Qi–Jian–Pi–Xiao–Yu–Xie–Zhuo Formula Improves Muscle Atrophy via Modulating the IGF-1/PI3K/Akt Signaling Pathway in 5/6 Nephrectomized Rats
por: Xia, Hong, et al.
Publicado: (2021)

Erratum: microRNA Crosstalk Influences Epithelial-to-Mesenchymal, Endothelial-to-Mesenchymal, and Macrophage-to-Mesenchymal Transitions in the Kidney
Publicado: (2020)

Therapeutic Targeting of Fibrotic Epithelial-Mesenchymal Transition–An Outstanding Challenge
por: Fintha, Attila, et al.
Publicado: (2019)

Implication of CD38 gene in podocyte epithelial-to-mesenchymal transition and glomerular sclerosis
por: Boini, Krishna M, et al.
Publicado: (2012)

Tangzhiqing Granules Alleviate Podocyte Epithelial-Mesenchymal Transition in Kidney of Diabetic Rats
por: Xu, Haiyan, et al.
Publicado: (2017)

Nanoapproaches to Modifying Epigenetics of Epithelial Mesenchymal Transition for Treatment of Pulmonary Fibrosis
por: Skibba, Melissa, et al.
Publicado: (2020)

GHK Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice by Suppressing TGFβ1/Smad-Mediated Epithelial-to-Mesenchymal Transition
por: Zhou, Xiao-Ming, et al.
Publicado: (2017)

Shikonin suppresses the epithelial-to-mesenchymal transition by downregulating NHE1 in bladder cancer cells
por: Mo, Lijun, et al.
Publicado: (2021)

Coptidis Rhizoma Suppresses Metastatic Behavior by Inhibiting TGF-β-Mediated Epithelial-Mesenchymal Transition in 5-FU-Resistant HCT116 Cells
por: Kang, Yong-Hwi, et al.
Publicado: (2022)

Colocynth Extracts Prevent Epithelial to Mesenchymal Transition and Stemness of Breast Cancer Cells
por: Chowdhury, Kaushik, et al.
Publicado: (2017)

Epoxyeicosatrienoic Acid Analog Decreases Renal Fibrosis by Reducing Epithelial-to-Mesenchymal Transition
por: Skibba, Melissa, et al.
Publicado: (2017)

Molecular mechanisms of COVID-19-induced pulmonary fibrosis and epithelial-mesenchymal transition
por: Pi, Peng, et al.
Publicado: (2023)

Mechanistic evaluation of the inhibitory effect of four SGLT-2 inhibitors on SGLT 1 and SGLT 2 using physiologically based pharmacokinetic (PBPK) modeling approaches
por: Zhang, Yu, et al.
Publicado: (2023)

Disabled-2 downregulation promotes epithelial-to-mesenchymal transition
por: Martin, J C, et al.
Publicado: (2010)

Sohlh2 suppresses epithelial to mesenchymal transition in breast cancer via downregulation of IL-8
por: Ji, Shufang, et al.
Publicado: (2016)

Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma
por: Lee, Jong Hyun, et al.
Publicado: (2020)

PTEN suppresses epithelial–mesenchymal transition and cancer stem cell activity by downregulating Abi1
por: Qi, Yanmei, et al.
Publicado: (2020)

Editorial: Molecular Mechanisms and New Therapeutic Targets in Epithelial to Mesenchymal Transition (EMT) and Fibrosis
por: Battistelli, Cecilia, et al.
Publicado: (2020)

IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights
por: Li, Heming, et al.
Publicado: (2017)

Src Activation Aggravates Podocyte Injury in Diabetic Nephropathy via Suppression of FUNDC1-Mediated Mitophagy
por: Zheng, Ting, et al.
Publicado: (2022)

Induced Pluripotent Stem Cells Inhibit Bleomycin-Induced Pulmonary Fibrosis in Mice through Suppressing TGF-β1/Smad-Mediated Epithelial to Mesenchymal Transition
por: Zhou, Yan, et al.
Publicado: (2016)

Methyl Gallate Suppresses the Migration, Invasion, and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells via the AMPK/NF-κB Signaling Pathway in vitro and in vivo
por: Liang, Huaguo, et al.
Publicado: (2022)

Characterization of the SGLT2 Interaction Network and Its Regulation by SGLT2 Inhibitors: A Bioinformatic Analysis
por: Wicik, Zofia, et al.
Publicado: (2022)

Long noncoding RNA ENSRNOG00000037522 is involved in the podocyte epithelial-mesenchymal transition in diabetic rats
por: Ling, Li, et al.
Publicado: (2018)

Effects of Montelukast on Arsenic-Induced Epithelial-Mesenchymal Transition and the Role of Reactive Oxygen Species Production in Human Bronchial Epithelial Cells
por: Chen, Huang-Chi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_q4ku653k1kpvvuhqirejb3nljs