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Low levels of tetracyclines select for a mutation that prevents the evolution of high-level resistance to tigecycline
In a collection of Escherichia coli isolates, we discovered a new mechanism leading to frequent and high-level tigecycline resistance involving tandem gene amplifications of an efflux pump encoded by the tet(A) determinant. Some isolates, despite carrying a functional tet(A), could not evolve high-l...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550176/ https://www.ncbi.nlm.nih.gov/pubmed/36170241 http://dx.doi.org/10.1371/journal.pbio.3001808 |