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Macrophage-Derived Exosomes in TLR9(−/−) Mice Ameliorate Sepsis-Induced Mitochondrial Oxidative Stress and Apoptosis in Cardiomyocytes

OBJECTIVE: To explore the mechanisms of TLR9 from macrophages on mitochondrial apoptosis in cardiomyocytes at early stage of sepsis. METHODS: The in vivo and in vitro sepsis mice were bone marrow transplantation (BMT) with wild type (WT) or (toll-like receptor 9) TLR9 knockout ((−/−) or KO) myeloid...

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Detalles Bibliográficos
Autores principales:	Li, Xiang, Luo, Junyu, Li, Yanmei, Jia, Lu, Li, Yuejin, Ye, Shili, Liu, Lanlan, Yu, Yanxuan, Lu, Yonggang, Luan, Yunpeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550441/ https://www.ncbi.nlm.nih.gov/pubmed/36225174 http://dx.doi.org/10.1155/2022/5719974

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