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ISG15 conjugation to proteins on nascent DNA mitigates DNA replication stress

The pathways involved in suppressing DNA replication stress and the associated DNA damage are critical to maintaining genome integrity. The Mre11 complex is unique among double strand break (DSB) repair proteins for its association with the DNA replication fork. Here we show that Mre11 complex inact...

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Detalles Bibliográficos
Autores principales: Wardlaw, Christopher P., Petrini, John H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550767/
https://www.ncbi.nlm.nih.gov/pubmed/36216822
http://dx.doi.org/10.1038/s41467-022-33535-y