Cargando…

Non-genetic stratification reveals epigenetic heterogeneity and identifies vulnerabilities of glycolysis addiction in lung adenocarcinoma subtype

Lung adenocarcinoma (LUAD) exhibits high heterogeneity and is well known for its high genetic variation. Recently, the understanding of non-genetic variation provides a new perspective to study the heterogeneity of LUAD. Little is known about whether super-enhancers (SEs) may be primarily responsibl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Xuming, Zhang, Te, Ding, Hanlin, Feng, Yipeng, Yang, Wenmin, Yin, Xuewen, Chen, Bing, Liang, Yingkuan, Mao, Qixing, Xia, Wenjie, Yu, Guiping, Xu, Lin, Dong, Gaochao, Jiang, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550819/ https://www.ncbi.nlm.nih.gov/pubmed/36216804 http://dx.doi.org/10.1038/s41389-022-00436-0

Ejemplares similares

circDCUN1D4 suppresses tumor metastasis and glycolysis in lung adenocarcinoma by stabilizing TXNIP expression
por: Liang, Yingkuan, et al.
Publicado: (2020)

Super-enhancer hijacking LINC01977 promotes malignancy of early-stage lung adenocarcinoma addicted to the canonical TGF-β/SMAD3 pathway
por: Zhang, Te, et al.
Publicado: (2022)

Different associations between organ-specific immune-related adverse event and survival in non-small cell lung cancer patients treated with programmed death-1 inhibitors-based combination therapy
por: Chen, Yuzhong, et al.
Publicado: (2023)

A novel gene expression signature-based on B-cell proportion to predict prognosis of patients with lung adenocarcinoma
por: Zhang, Yi, et al.
Publicado: (2021)

Tobacco exposure primes the secretion of CCL21 positively associated with tertiary lymphoid structure and response to immunotherapy
por: Yin, Xuewen, et al.
Publicado: (2023)

Tertiary lymphoid structures favor outcome in resected esophageal squamous cell carcinoma
por: Li, Rutao, et al.
Publicado: (2022)

PKM2 and cancer: The function of PKM2 beyond glycolysis
por: DONG, GAOCHAO, et al.
Publicado: (2016)

CircIMMP2L promotes esophageal squamous cell carcinoma malignant progression via CtBP1 nuclear retention dependent epigenetic modification
por: Liang, Yingkuan, et al.
Publicado: (2021)

CircCNTNAP3-TP53-positive feedback loop suppresses malignant progression of esophageal squamous cell carcinoma
por: Wang, Hui, et al.
Publicado: (2020)

The TWIST1-centered competing endogenous RNA network promotes proliferation, invasion, and migration of lung adenocarcinoma
por: Xia, Wenjie, et al.
Publicado: (2019)

Aberrant super-enhancer landscape reveals core transcriptional regulatory circuitry in lung adenocarcinoma
por: Zhang, Te, et al.
Publicado: (2020)

Upregulated Collagen COL10A1 Remodels the Extracellular Matrix and Promotes Malignant Progression in Lung Adenocarcinoma
por: Liang, Yingkuan, et al.
Publicado: (2020)

Circular RNA circCRIM1 inhibits invasion and metastasis in lung adenocarcinoma through the microRNA (miR)‐182/miR‐93‐leukemia inhibitory factor receptor pathway
por: Wang, Lin, et al.
Publicado: (2019)

SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWAS
por: Yang, Wenmin, et al.
Publicado: (2022)

The super-enhancer-driven lncRNA LINC00880 acts as a scaffold between CDK1 and PRDX1 to sustain the malignance of lung adenocarcinoma
por: Feng, Yipeng, et al.
Publicado: (2023)

Clinical and prognostic implications of an immune‐related risk model based on TP53 status in lung adenocarcinoma
por: Song, Xuming, et al.
Publicado: (2021)

CT-Based Deep Learning Model for Invasiveness Classification and Micropapillary Pattern Prediction Within Lung Adenocarcinoma
por: Ding, Hanlin, et al.
Publicado: (2020)

BRD9 is an essential regulator of glycolysis that creates an epigenetic vulnerability in colon adenocarcinoma
por: Zhu, Qunshan, et al.
Publicado: (2022)

Gut Microbiota Shapes the Efficiency of Cancer Therapy
por: Ma, Weidong, et al.
Publicado: (2019)

High‑risk pathological subtype associated FAM83A‑AS1 promotes malignancy and glycolysis of lung adenocarcinoma via miR‑202‑3p/HK2 axis
por: Xiong, Xinkui, et al.
Publicado: (2023)

DNA Epigenetics in Addiction Susceptibility
por: Kaplan, Graham, et al.
Publicado: (2022)

N (6)‐methyladenosine‐modified circFUT8 competitively interacts with YTHDF2 and miR‐186‐5p to stabilize FUT8 mRNA to promote malignant progression in lung adenocarcinoma
por: Dong, Gaochao, et al.
Publicado: (2023)

The Long Noncoding RNA LINC00665 Facilitates c-Myc Transcriptional Activity via the miR-195-5p MYCBP Axis to Promote Progression of Lung Adenocarcinoma
por: Wang, Anpeng, et al.
Publicado: (2021)

Predictive Value of Ercc1 and Xpd Polymorphisms for Clinical Outcomes of Patients Receiving Neoadjuvant Therapy: A Prisma-Compliant Meta-Analysis
por: Qixing, Mao, et al.
Publicado: (2015)

Microarray analyses reveal genes related to progression and prognosis of esophageal squamous cell carcinoma
por: Qixing, Mao, et al.
Publicado: (2017)

Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer
por: Xia, Wenjie, et al.
Publicado: (2019)

Diisopropylamine dichloroacetate enhances radiosensitization in esophageal squamous cell carcinoma by increasing mitochondria-derived reactive oxygen species levels
por: Dong, Gaochao, et al.
Publicado: (2016)

Self-restricted circular RNA circSOX2 suppressed the malignant progression in SOX2-amplified LUSC
por: Liang, Yingkuan, et al.
Publicado: (2022)

DNA methylation mediated silencing of microRNA-145 is a potential prognostic marker in patients with lung adenocarcinoma
por: Xia, Wenjie, et al.
Publicado: (2015)

Epigenetics, microRNA, and addiction
por: Kenny, Paul J.
Publicado: (2014)

Epigenetic Priming in Drug Addiction
por: Mews, Philipp, et al.
Publicado: (2019)

CAG repeat polymorphisms in the androgen receptor and breast cancer risk in women: a meta-analysis of 17 studies
por: Mao, Qixing, et al.
Publicado: (2015)

Young age increases risk for lymph node positivity but decreases risk for non-small cell lung cancer death
por: Xia, Wenjie, et al.
Publicado: (2018)

Integrative analysis of differential genes and identification of a “2‐gene score” associated with survival in esophageal squamous cell carcinoma
por: Wang, Lin, et al.
Publicado: (2018)

Improvement of survival for non-small cell lung cancer over time
por: Xia, Wenjie, et al.
Publicado: (2017)

The molecular, immune features, and risk score construction of intraductal papillary mucinous neoplasm patients
por: Huang, Xing, et al.
Publicado: (2022)

Implications of circadian rhythm and stress in addiction vulnerability
por: Becker-Krail, Darius, et al.
Publicado: (2016)

Neurobiology of opioid dependence in creating addiction vulnerability
por: Evans, Christopher J., et al.
Publicado: (2016)

On the early-life origins of vulnerability to opioid addiction
por: Levis, Sophia C, et al.
Publicado: (2019)

Epigenetic mechanisms involved in methamphetamine addiction
por: Wang, Hang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_caklj88lg5tgcpstj3lvhio6p3