Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB(2)R)

It is well known that G protein–coupled receptors (GPCRs) assume multiple active states. Orthosteric ligands and/or allosteric modulators can preferentially stabilize specific conformations, giving rise to pathway-biased signaling. One of the most promising strategies to expand the repertoire of sig...

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Detalles Bibliográficos
Autores principales: Ferrisi, Rebecca, Gado, Francesca, Polini, Beatrice, Ricardi, Caterina, Mohamed, Kawthar A., Stevenson, Lesley A., Ortore, Gabriella, Rapposelli, Simona, Saccomanni, Giuseppe, Pertwee, Roger G., Laprairie, Robert B., Manera, Clementina, Chiellini, Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551276/
https://www.ncbi.nlm.nih.gov/pubmed/36238097
http://dx.doi.org/10.3389/fchem.2022.984069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551276/
https://www.ncbi.nlm.nih.gov/pubmed/36238097
http://dx.doi.org/10.3389/fchem.2022.984069

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