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KRAS protein expression becomes progressively restricted during embryogenesis and in adulthood

KRAS mutants are common in many cancers and wild-type KRAS is essential in development as its absence causes embryonic lethality. Despite this critical role in development and disease, the normal expression pattern of KRAS protein is still largely unknown at the tissue level due to the lack of valid...

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Detalles Bibliográficos
Autores principales: Minati, Marie-Albane, Assi, Mohamad, Libert, Maxime, Cordi, Sabine, Lemaigre, Frédéric, Jacquemin, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551567/
https://www.ncbi.nlm.nih.gov/pubmed/36238685
http://dx.doi.org/10.3389/fcell.2022.995013