Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo

Osteoarthritis (OA) is a common degenerative joint disease. Effective drugs that can halt or decelerate osteoarthritis progression are still lacking. Omaveloxolone is a semisynthetic oleanane triterpenoid exerting antioxidative and anti-inflammatory effects. The present study aims to determine wheth...

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Detalles Bibliográficos
Autores principales: Jiang, Zengxin, Qi, Guobin, Lu, Wei, Wang, Hao, Li, Defang, Chen, Weibin, Ding, Lei, Yang, Xiuying, Yuan, Hengfeng, Zeng, Qingmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551575/
https://www.ncbi.nlm.nih.gov/pubmed/36238561
http://dx.doi.org/10.3389/fphar.2022.952950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9551575/
https://www.ncbi.nlm.nih.gov/pubmed/36238561
http://dx.doi.org/10.3389/fphar.2022.952950

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